• Acetazolamide - FDA prescribing information, side effects and uses

    Acetazolamide is available for intravenous use, and is supplied as a sterile powder reconstitution. Each vial contains acetazolamide sodium equivalent to mg of acetazolamide. Administer IV when rapid of IOP is necessary or if patient is unable to take oral medication. a e. Reconstitution. Reconstitute vial mg of acetazolamide with 5 mL of sterile water for injection to provide a solution mg/mL. a e. Dosage/ mg-1 g PO/IV qDay or divided qhr; Sustained-release: mg PO q12hr; Secondary glaucoma. mg PO/IV, followed by mg PO q4hr; Sustained-release: mg PO q12hr; Acute Altitude. A mean dose of +/- mg/kg/dose given IV or PO every 6 to 8 hours for 3 to 24 doses was used in a study of critically ill pediatric patients (n = 34, age 18 days to 12 years) with metabolic alkalosis (pH greater than and HCO3 greater than 26 mEq/L). Oct 24,  · Initial dose: to mg orally/IV once a day -If after initial response there is a lack of response, hold therapy for a day Maintenance dose: One dose every other day or once a day for 2 days with a day of rest/ Feb 15,  · Acetazolamide is available for intravenous use, and is supplied as a sterile powder reconstitution. Each vial contains acetazolamide sodium equivalent to mg of acetazolamide. The bulk solution is adjusted to pH sodium hydroxide and, if necessary, hydrochloric acid prior to lyophilization. Acetazolamide yields best diuretic results when given on alternate days, or for two days with a day of rest. Failures in therapy may be due to overdosage or too frequent dosage. The use of acetazolamide does not eliminate the need for other therapy .

    Acetazolamide should be used as an adjunct to the usual therapy. A complementary effect has been noted when Acetazolamide has been used in conjunction with miotics or mydriatics as the case demanded. Consult drug interactions database for more detailed information. Distributed into erythrocytes, renal cortex, and aqueous humor of eye. McEvoy GK, ed. Retrieved 5 June However, an IV push rate of up to mg over 3 minutes has been reported in a clinical trial Mazur The suggested total daily dose is 8 to 30 mg per kg in divided doses. Alteration in ammonia metabolism occurs due to increased reabsorption of ammonia by the renal tubules as a result of urinary alkalinization. Intravenous therapy may be used for rapid relief of ocular tension in acute cases.

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