• Torsemide versus Furosemide in Heart Failure Patients: Insights from Duke University Hospital

    Lasix (furosemide) and Demadex (torsemide) are diuretics (water pills) used to treat edema (water retention) due to congestive heart failure, kidney disease, chronic kidney failure, or liver disease. Lasix and Demadex are also used with other high blood pressure medications to . Torsemide mg is approximately equivalent to 1 mg of bumetanide and 40 mg of furosemide. The potent diuretic effect of torsemide can cause the loss of large amounts of body water to dehydration as well as the loss of electrolytes (for example, sodium, potassium, magnesium, and calcium). Therefore, careful medical supervision is necessary treatment. Jun 05,  · Initial dose: 20 to 80 mg orally once; may repeat with the same dose or increase by 20 or 40 mg no sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtained. Maintenance dose: Administer the dose that provided the desired diuretic effect once or twice a day (e.g., at 8 am and 2 pm). INTRODUCTION. Loop diuretics furosemide and torsemide are prescribed for the treatment of symptomatic heart failure (HF) 1, ryloa.linkpc.nett HF guidelines indicate that loop diuretics are a central treatment for the management of volume overload ryloa.linkpc.neted with furosemide, torsemide has increased bioavailability and a longer half-life 4, yet furosemide remains the most commonly used Cited by: Compare Furosemide vs Torsemide head-to-head with other drugs for uses, cost, side effects, interactions and more. Furosemide rated /10 vs Torsemide rated /10 in . Loop diuretic conversion - Equivalent Doses Furosemide (Lasix) 40 mg PO = Furosemide 20 mg IV = Torsemide 20 mg PO/IV = Bumetanide (Bumex) 1 mg PO/IV #Pharmacology #Cardiology #Loop #Diuretic #Equivalent #Doses #Conversion #Table #Furosemide #Torsemide #Bumex #Lasix #Bumetanide ** GrepMed Recommended Text: Clinical Pharmacology Made Ridiculously Simple - . Mar 02,  · Comments: Chronic use of any diuretic in hepatic disease has not been studied adequately. Usual Adult Dose for Hypertension. 5 mg orally once a day; if diuresis remains inadequate after 4 to 6 weeks, titrate up to 10 mg orally once a day; if diuresis remains inadequate with 10 mg, an additional antihypertensive should be added. Renal Dose / It has been shown that torsemide at 1/10 th the dose of furosemide produces equivalent diuresis in dogs, and that torsemide’s duration of action is approximately twice that of furosemide (12 h vs. h). 3 A case series of 3 dogs with advanced heart failure described use of torsemide to achieve apparent long-term resolution of CHF in patients previously frequent relapses (suspected . There are 3 loop diuretics which have the dose conversion of mg. Furosemide is the most commonly used to treat edema and is a ratio of IV:PO. If patient's do not respond well to furosemide, to bumetanide or torsemide may be effective as they have higher bioavailability than furosemide.

    Address for correspondence : Robert J. Commonly reported side effects include: polyuria. Table 4 presents the outcomes data in patients treated with furosemide or torsemide. Acknowledgments Funding: No extramural funding. From an online gift to a charitable gift annuity, your contribution will have a significant impact in the lives of thousands of animals. Use: Treatment of edema associated with congestive heart failure, cirrhosis of the liver and renal disease, including the nephrotic syndrome, especially when an agent with greater diuretic potential is desired. Third, previous studies suggesting an association between torsemide and outcomes were conducted in the chronic HF populations 13 rather than those recently hospitalized with HF. Schulte , PhD, a Adam D. Life Sci. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. We described baseline characteristics based on discharge diuretic and assessed the relationship with all-cause mortality through 5 years. Studies that were conducted even prior to the widespread availability of generic torsemide 23 suggest that despite a previously higher acquisition cost, torsemide may be associated with a reduction in total cost per patient. FDA Safety Alerts for all medications. Torsemide was generally well tolerated in these cats with heart failure and a high diuretic requirement, although increased azotemia and decreased potassium were noted in both groups of cats at the first recheck, with a proportion of cats in both series requiring reduced torsemide dosing during chronic use due to azotemia.

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