Reactogenicity and immunogenicity of bivalent influenza vaccine in one- and two-dose trials in children: a summary. A Disclosure of Relationships may be found on page However, age indications for the various individual IIVs differ Table 1. In a multicenter observer-blind trial in which 2, children aged 5 through 17 years were randomized to receive Afluria Quadrivalent or a licensed comparator IIV4, Afluria Quadrivalent met criteria for noninferior immunogenicity for all four vaccine virus strains IIVs and RIV4 may be administered concomitantly or sequentially with other inactivated vaccines or with live vaccines. This report focuses on the recommendations for use of influenza vaccines for the prevention and control of influenza during the —19 season in the United States. Other content experts and CDC planners wish to disclose they have no financial interests or other relationships with the manufacturers of commercial products, suppliers of commercial services, or commercial supporters. In addition to potential safety issues, immune response to live or inactivated vaccines might be blunted in some clinical situations, such as for persons with congenital immune deficiencies, persons receiving cancer chemotherapy, and persons receiving immunosuppressive medications. An attached dose-divider clip is removed from the sprayer to administer the second half of the dose into the other nostril. Not all products are likely to be uniformly available in any practice setting or locality.

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