Moderate The therapeutic effect of phenylephrine may be decreased in patients receiving benzodiazepines. Read and follow these instructions carefully. It is not known if lorazepam is safe and effective for use for longer than 4 months. Related Stories. Although lorazepam has a shorter elimination half-life than diazepam, lorazepam persists in the CNS longer than diazepam. Lorazepam passes into your breast milk and may harm your baby. If a benzodiazepine must be used, a short-acting agent such as oxazepam or lorazepam should be selected, and administered at the minimum dosage and duration required for symptom relief. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. May be used off label for acute seizures that have not yet progressed to status epilepticus. The usual precautions for treating patients with impaired renal and hepatic function should be observed. If used together, a reduction in the dose of one or both drugs may be needed. Flumazenil has minimal effects on benzodiazepine-induced respiratory depression; suitable ventilatory support should be available, especially in treating acute benzodiazepine overdose.

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